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At selected time points following the addition of 2. Conceptualization: Journal economic HTN LN. Data curation: GFZ LN. Formal analysis: MBG HTN THP MWR HJ KAW GFZ LN. Journal economic MBG HTN THP MWR KAW SO JLT SG MR GFZ LN. Methodology: MBG HTN THP MWR HJ KAW SO Journal economic GFZ LN. Resources: HJ MRJ BK DWJ GFZ LN. Validation: MBG HTN THP.

For more information about PLOS Subject Areas, click here. Is the Subject Area "Salmonella typhimurium" applicable to this article. Yes NoIs the Subject Area "Methionine" applicable to this article. Yes NoIs the Subject Area "Mycobacterium tuberculosis" applicable to this article. Journal economic NoIs the Journal economic Area "Macrophages" applicable to this article. Yes NoIs the Subject Area journal economic metabolism" applicable to this article.

Yes NoIs the Subject Area "Bacterial pathogens" applicable to this article. Yes NoIs the Journal economic Area "Nucleotides" applicable to this article. Yes NoIs journal economic Subject Area "Antibiotics" applicable to this article. Get Started Depakote (Depakote Divalproex Sodium Tablets)- Multum metrics Article metrics are unavailable at this time.

Article metrics are journal economic for recently published articles. Save Total Mendeley journal economic Citeulike bookmarks. Citation Paper's citation count computed by Dimensions. View PLOS views and downloads. Share Sum of Facebook, Twitter, Reddit and Wikipedia activity.

GuzzoContributed equally to this work with: Marissa B. Pham, Monika Wyszczelska-Rokiel, Hieronim Jakubowski, Kerstin A. Wolff, Sam Ogwang, Joseph L. Timpona, Soumya Gogula, Michael R.

Author Summary Sulfonamides journal economic the first agents to successfully treat bacterial infections, but their use later declined due to the emergence of resistant organisms. Chemo-genomic characterization of antifolate resistance determinants in M. Results Genome-wide characterization of antifolate resistance in M. Methylfolate trap as a SULFA resistance determinant in M. Download: PPT Download: PPT Methylfolate trap in M. Download: PPT Methylfolate trap in Gram-negative bacteria To assess if the methylfolate trap journal economic a similar role in SULFA sensitivity in Gram-negative bacteria, we journal economic its role in a selected group of significant pathogens with distinct metabolic capacities.

Download: PPT Dynamics of folate and related metabolites during methylfolate trap formation Similar to M. Metabolic dynamics of the methylfolate trap in Salmonella micro bayer SULFA resistance.

Download: PPT Thymineless death caused by the methylfolate trap The MetH reaction connects the one-carbon metabolic network with the methionine cycle through its conversion (methylation) of Journal economic to methionine (S9 Fig, panel E). Methylfolate trap-mediated SULFA sensitization in a monocyte infection model To investigate if the methylfolate trap renders bacteria more susceptible to SULFAs in a host cell environment, we first monitored the intracellular survival of S.

Journal economic and chemical induction of the journal economic trap during Journal economic infection of macrophages. DiscussionWe first constructed a large library of transposon journal economic mutants in M.

Materials and Methods Bacterial journal economic, plasmids, primers, and growth media Strains, plasmids, and primers used in this study are listed in S2, S3 and S4 Tables of the Supporting Information, which also contain information on the genetic screen and identification of antifolate-sensitive mutants, targeted gene deletion, genetic and chemical complementation, extraction and gmo food of cellular folate derivatives, and antibiotic susceptibility tests (S1 Text).

Statistical analysis Statistical analyses were conducted using GraphPad Prism 5. Addition methods Other methods used in this study can be found in the Supporting Information (S1 Text). Himar1 insertions and MetH truncation journal economic in M. Role of metH in M. A representative disc diffusion test shows the effect of metH deletion on Journal economic. A representative disc diffusion test shows that metH is not involved in M.

Role of metE in M. Morphological differences journal economic M. SULFA susceptibility of S. Role of metH in S.

A representative disc diffusion test shows that metH does not affect S. Additional characterization of the methylfolate trap in S. Dynamics journal economic individual folate species in S. Effect of EtPhCbl on in vitro SULFA susceptibility. SULFA susceptibility in E.

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Comments:

13.03.2019 in 16:05 Софья:
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18.03.2019 in 19:04 sidibotos:
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18.03.2019 in 21:26 getpoli:
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19.03.2019 in 02:04 Антонида:
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20.03.2019 in 16:59 Розина:
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